Creatinine Clearance Calculator

Calculate estimated glomerular filtration rate (eGFR) and creatinine clearance with multiple formulas. Designed for UK healthcare professionals.

Important Disclaimer: This calculator is for informational purposes only and should be used under the guidance of a healthcare professional. Kidney function assessment requires proper clinical evaluation. Medication dosing decisions based on creatinine clearance should be made by qualified healthcare providers.
Patient Information
Normal range: 60-120 μmol/L (male), 45-90 μmol/L (female)
About This Calculator

This calculator provides estimates of kidney function using three common formulas:

  • Cockcroft-Gault: Estimates creatinine clearance in mL/min.
  • MDRD (Modification of Diet in Renal Disease): Estimates GFR in mL/min/1.73m².
  • CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration): The most accurate formula for eGFR calculation, especially in the higher GFR range.

The CKD staging follows UK NICE guidelines (NG203, 2021) for chronic kidney disease management.

Note: These formulas provide estimates only and should be interpreted in clinical context by qualified healthcare professionals.
Medical Information
Formula Details

Cockcroft-Gault Formula:

CrCl (mL/min) = [(140 - Age) × Weight × (0.85 if female)] / (72 × Serum Creatinine in mg/dL)

MDRD Formula (4-variable):

eGFR (mL/min/1.73m²) = 175 × (Serum Creatinine in mg/dL)-1.154 × (Age)-0.203 × (0.742 if female) × (1.212 if Black)

CKD-EPI Formula:

eGFR = 141 × min(SCr/κ, 1)α × max(SCr/κ, 1)-1.209 × 0.993Age × (1.018 if female) × (1.159 if Black)

Where κ is 0.7 for females and 0.9 for males, α is -0.329 for females and -0.411 for males, SCr is serum creatinine in mg/dL.

CKD Staging (NICE Guidelines)
Stage GFR (mL/min/1.73m²) Description
G1 ≥90 Normal or high
G2 60-89 Mildly reduced
G3a 45-59 Mildly to moderately reduced
G3b 30-44 Moderately to severely reduced
G4 15-29 Severely reduced
G5 <15 Kidney failure
References
  1. National Institute for Health and Care Excellence (NICE). (2021). Chronic kidney disease: assessment and management (NG203).
  2. Cockcroft DW, Gault MH. (1976). Prediction of creatinine clearance from serum creatinine. Nephron, 16(1):31-41.
  3. Levey AS, et al. (1999). A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Ann Intern Med, 130(6):461-470.
  4. Levey AS, et al. (2009). A new equation to estimate glomerular filtration rate. Ann Intern Med, 150(9):604-612.