Creatinine Clearance Calculator

Calculate estimated glomerular filtration rate (eGFR) and creatinine clearance with multiple formulas. Designed for UK healthcare professionals.

Important Clinical Disclaimer: The Creatinine Clearance Calculator is intended for use by qualified healthcare professionals only. It is for educational and informational purposes and should not replace clinical judgement. Always interpret results alongside the full clinical picture and follow your local guidelines and protocols.
Patient Information
Normal range: 60-120 μmol/L (male), 45-90 μmol/L (female)
About This Calculator

This calculator provides estimates of kidney function using three common formulas:

  • Cockcroft-Gault: Estimates creatinine clearance in mL/min.
  • MDRD (Modification of Diet in Renal Disease): Estimates GFR in mL/min/1.73m².
  • CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration): The most accurate formula for eGFR calculation, especially in the higher GFR range.

The CKD staging follows UK NICE guidelines (NG203, 2021) for chronic kidney disease management.

This result is for guidance only. Clinical judgement should always take precedence.
Medical Information
Formula Details

Cockcroft-Gault Formula:

CrCl (mL/min) = [(140 - Age) × Weight × (0.85 if female)] / (72 × Serum Creatinine in mg/dL)

MDRD Formula (4-variable):

eGFR (mL/min/1.73m²) = 175 × (Serum Creatinine in mg/dL)-1.154 × (Age)-0.203 × (0.742 if female) × (1.212 if Black)

CKD-EPI Formula:

eGFR = 141 × min(SCr/κ, 1)α × max(SCr/κ, 1)-1.209 × 0.993Age × (1.018 if female) × (1.159 if Black)

Where κ is 0.7 for females and 0.9 for males, α is -0.329 for females and -0.411 for males, SCr is serum creatinine in mg/dL.

CKD Staging (NICE Guidelines)
Stage GFR (mL/min/1.73m²) Description
G1 ≥90 Normal or high
G2 60-89 Mildly reduced
G3a 45-59 Mildly to moderately reduced
G3b 30-44 Moderately to severely reduced
G4 15-29 Severely reduced
G5 <15 Kidney failure
References
  1. National Institute for Health and Care Excellence (NICE). (2021). Chronic kidney disease: assessment and management (NG203).
  2. Cockcroft DW, Gault MH. (1976). Prediction of creatinine clearance from serum creatinine. Nephron, 16(1):31-41.
  3. Levey AS, et al. (1999). A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Ann Intern Med, 130(6):461-470.
  4. Levey AS, et al. (2009). A new equation to estimate glomerular filtration rate. Ann Intern Med, 150(9):604-612.
Disclaimer

This calculator is provided for educational and informational purposes only. It is not intended to be a substitute for professional medical advice, diagnosis, or treatment.

  • Always seek the advice of a qualified healthcare provider with any questions regarding a medical condition.
  • Never disregard professional medical advice or delay seeking it because of information from this tool.
  • Clinical decision-making should always incorporate the full clinical context, patient preferences, and local protocols.
  • The creators of this tool accept no liability for decisions made based on its output.

If you are a patient: please discuss any results with your healthcare provider. This tool is designed for use by medical professionals and may not be appropriate for self-assessment.